Computational Bioscience is an open access journal featuring research articles that combine biological and computational research to enhance the scientific understanding of life. The discipline of computational bioscience, like the field of genomics, is expected to undergo enormous growth. As the current generation of bioinformaticians and molecular biologists map functional elements of genomes and use that information to make scientific discoveries, they will enable diagnoses and management of human diseases. As a community, successful management of this growth in knowledge requires recognition of advancements to the field and public access to the data. Resources such as this journal will do so with the goal of fostering development of a new generation of computational methods that help biologists deal with the complexity of the emerging or shifting biological paradigms as they continue to incorporate novel outcomes of major scientific consortiums.