E. Martín-Badosa, A. Elmoutaouakkil, S. Nuzzo (Spain/France), D. Amblard, L. Vico (France), and F. Peyrin (Spain/France)
Medical imaging, computed microtomography, bone micro architecture, 3D analysis.
We developed an automatic method to characterize
mice bone architecture from 3D microtomographic
images. The distal metaphyses of the femur of mice
were imaged using 3D synchrotron radiation
microtomography at the ESRF (ID19) with a voxel size
of 6.65 µm. Within each reconstructed volume, a region
of interest was defined and trabecular and cortical bones
were automatically separated. Then, 3D morphologic
and topologic model-independent parameters
quantifying the three-dimensional bone architecture
were computed in both regions. The technique was
applied to study the response of the C57BL/6J@Ico
strain of mice submitted to a model of bone loss by hind
limb unloading produced by tail-suspension.