Towards Reagent-free Continuous Blood Glucose Monitoring for the Critical Care Environment using Micro-Dialysis and Infrared Spectrometry

O. Vogt, U. Damm, and H.M. Heise (Germany)


glucose, infrared spectrometry, micro-dialysis, continuous monitoring


Recently, enormous interest has been turned to quasi continuous analysis of glycaemia in the intensive care discipline. For patients under critically ill conditions, the intensive insulin therapy treatment requires reliable assays for blood glucose. Micro-dialysis in combination with infrared spectrometric detection renders a system that can function reagent- and calibration-free over an extended period. A programmable fluidics system has been set-up and tested which allows regular spectral sample and reference measurements. Such instrumentation suits the low pressure conditions necessary for microdialysis and the high pressure for transport flow to the flow-through infrared micro-cell. First assay results are presented.

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