Preparation of Polyurethane / Hydroxyapatite Composite Scaffold for Tissue Regeneration

A. Asefnejad, A. Behnamghader, and M. T. Khorasani (Iran)


Tissue engineering, Composite, Polyurethane, HA


In this study, a new composites scaffold of hydroxyapatite (HA)/polyurethane (PU) were prepared by thermally induced solid–liquid phase separation (TIPS). The morphology, chemical bonding and mechanical properties of the scaffolds were investigated by SEM, FTIR and compression testing. The SEM pictures Exhibited regular and interconnected porosity. The pore volume decreased with increasing amounts of HA into the scaffold. The SEM images have shown that the samples had pore size with ranging from 50-200 µm. The water absorption of the composite foams was investigated with phosphate buffer saline (PBS). The addition of hydroxyapatite to polymer foams increased the water absorption. The HA/PU scaffold exhibited good biocompatibility estimated by culturing the scaffold with L-929 fibroblast cell line. Such polyurethane composite scaffolds have good prospects to be used as biodegradable and bioactive scaffolds in bone tissue engineering.

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