Parameter Estimation on Algebraic Systems: Application to Sequence Dependent Structure of DNA

S. Hawley and H. Chizeck (USA)


Algebraic Systems, DNA, Sequence Dependent Structure


Sequence dependent structure might be a factor in the con trol of gene expression. But the interactions between nu cleotides are complex and tradeoffs must be made to create a simple model which performs well in general. In this work such a model has been created using algebraic sys tems theory and a genetic algorithm to estimate the model parameters. The model derived is compared to a well devel oped model present in the literature and found to be statisti cally equivalent in terms of the root mean square deviations (RMSD) of the predicted structures.

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