Preparation of Syndiotactic Poly(Vinyl Alcohol) Nanoparticles for Drug Delivery System

W.S. Lyoo, J.W. Kwak, S.H. Cho, S.S. Han, S.K. Noh, H.G. Choi, and C.S. Yong (Korea)


Syndiotactic, poly(vinyl alcohol), diclofenac, and homogenizer


Watersoluble syndiotactic poly(vinyl alcohol) (PVA) prepared by bulk-copolymerization of vinyl acetate (VAc) and vinyl pivalate (VPi) using 2,2'-azobis(2,4-dimethyl valeronitrile) (ADMVN) was used for obtaining perfectly spherical shaped and separated PVA nanoparticles. Atactic PVA (a-PVA) nanoparticles have showed limitations as the drug delivery material due to the poor persistence and aggregation property of a-PVA. The s PVA gel nanoparticles containing drugs prepared by homogenization using water-in-oil (W/O) emulsion system are expected as an ideal drug delivery material with better efficacy and fewer side-effects.

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