Concentraton Polarization of Macromolecules at an Arterial Stenosis of Canine Carotid

X. Deng and Y. Fan (PRC)


Concentration polarization, flow disturbance, arterial stenosis, atherosclerosis


To verify our previous theoretical prediction that disturbed flow distal to a stenosis enhances lipid accumulation at the blood/arterial wall interface, luminal surface albumin concentration was measured directly using a canine carotid arterial stenosis model. The results from the experiment demonstrated that due to the presence of a filtration flow, macromolecules accumulated at the blood/arterial wall interface. The luminal surface concentration of macromolecules can indeed be significantly enhanced in regions of disturbed flow.

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