Numerical Simulation of Low Density Lipoprotein (LDL) Transport in Arterial Stenoses

X. Deng (PRC, Canada), N. Fatouraee, and R. Guidoin (PRC)


Atherosclorosis, hemodynamics, mass transport, water permeability, low density lipoprotein


The transport of atherogenic lipids (LDL) in an arterial stenosis with a semi-permeable wall was simulated numerically. The numerical analysis predicted lipid accumulation at the blood/arterial wall interface, with the highest concentration occurring at the flow separation point right distal to the summit of the stenosis. The analysis also predicted that the larger the Schmidt number (i.e., the larger the lipids), the higher the peak value of the luminal surface lipid concentration. The fluid layer with highly concentrated lipids in the area of flow separation point may be responsible for the formation and development of the arterial stenosis.

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