Correlation Analysis between Remifentanil and Other Signals Recorded during ICU Anesthesia

F. Robayo, D. Sendoya, R. Hodrea, C. Ionescu, and R. de Keyser (Belgium)


Correlation, Anesthesia, Analgesia, Biomedical signals


The level of pain cannot be directly measured in patients under general anesthesia. In order to find a surrogate variable which can be used to measure the analgesic (pain) level, a correlation analysis is performed between Remifentanil (analgesic drug) and other biomedical signals recorded during Intensive Care Unit (ICU) anesthesia. The results obtained are presented in this paper. The signals used in this study were recorded in the Ghent University Hospital during clinical trials on 6 patients. The patients have undergone cardiac surgery prior to ICU. Correlation coefficients were taken into account to identify which of these variables are correlated with the Remifentanil signal. The bispectral index (BIS), the electromyography (EMG) and the respiration rate oxygen measurement (O2) proved to be correlated with Remifentanil, although there are some exceptions, due to the low quality of the data. For the non-invasive blood pressure (NIBP) and the respiration rate from carbon dioxide measurement (CO2) lower degree of correlation was obtained. The results of this study give some suggestions upon which signals can be used further to derive a surrogate variable for pain measurement, towards a MIMO (multiple-input multiple-output) model for Propofol and Remifentanil administration in ICU.

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