Comparison of Control Theoretic Properties of Models of Antiangiogenic Therapy

A. Swierniak (Poland)


biomedical modelling, nonlinear systems, optimal control, antiangiogenic therapy


Six models of antiangiogenic therapy are compared and analyzed from control theoretic point of view. All of them consist of a model of tumor growth bounded by the capacity of a vascular network developed by the tumor in the process of angiogenesis and different model of dynamics of this network and they are based on the idea proposed by Hahnfeldt et al. Moreover we analyse optimal control problems resulted from their use to treatment protocols design.

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