An Evaluation of Motif Detection Tools

Alin G. Voina, Petre G. Pop, and Mircea-Florin Vaida


bioinformatics, motif finding algorithms, gene expression, regulatory elements, computational methods


The process of gene regulation remains an active challenge for the researchers in molecular biology field. The main focus in this area is to understand the process that is behind gene regulation so that we can form an idea about biological evolution and adaptation. A good start in understanding the evolution of genes is by searching for DNA binding sites for transcription factors. These binding sites are formed mainly from short DNA segments known as motifs. In the last decades, the advances in genome sequence have led to the development of various computational methods for motif finding. In this study, we analyzed some of the most popular computational methods and we present a performance analysis of the existing approaches.

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