Control Properties of Two- and Three-Compartmental Models of Combined Anticancer Therapy

Andrzej Swierniak and Malgorzata Dolbniak


Combined anticancer therapy, biomedical modeling, antiangiogenic treatment


We present results of analysis and simulation experiments for a class of two- and three compartmental models of tumor response to anticancer combined therapy. Treatment protocols are treated as control actions for a dynamical system which describes vascular growth of tumor. The therapy consists of direct modality represented by chemotherapy and indirect one in the form of antiangiogenic therapy. We discuss differences in control properties of the models and compare results of simulations of theoretical and realistic protocols.

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