3D Modelling and Structural Simulation of Scaffolds for Cardiovascular Implants

Janaina de A. Dernowsek, Rodrigo A. Rezende, Pedro Y. Noritomi, Daniel T. Kemmoku, Julia A. Nogueira, Vladimir Mironov, and Jorge V. L. da Silva


3-Dimensional Modelling, Medicine,, Cardiovascular Implants, Structural Simulation


Cardiovascular disease remains as one of the main problems in contemporary health care worldwide. Several studies of the cardiac prostheses have been held since 60s with the advent of cardiopulmonary bypass. The mechanical properties of blood vessels, arteries and valves depend on collagen and elastic fibers, as well as on smooth muscle cells and ground substances. Many works about three-dimensional finite element model of the arterial wall segment and the heart valves assume the biological material to be homogeneous and isotropic. This configuration is a simplified way to reduce the complexity of biological structures. The primary purpose of this study was to assess the effects of fiber design and orientation on the stress distribution in a 3D model for cardiovascular implants and predict the elastic modulus of scaffolds designed.

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